ABSTRACT
Aegle marmelos L, Eclipta alba L. and Phyllanthus amarus are well known herbs as hepatoprotective agents. The preventive effects of polyherbal formulation containing the above herbs were evaluated against carbon tetra chloride [CCI[4]] induced hepatotoxicity in rats. CCI[4] induced fatty degeneration and vacuole formation and significantly increased the levels of alanine aminotransferase [ALT] and aspartate aminotransferase [AST] in rat's plasma. Treatment with the herbal formulation significantly decreased the levels of AST and ALT in plasma. Also histopathological studies showed that the formulation reduced the incidence of liver lesions induced by CCI[4]. The study proved that the formulation prepared from A. marmelos, P. amarus and E. alba may be used in the treatment of CCI[4] induced hepatotoxicity
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the anti-inflammatory property of the leaf exacts of Gendarussa vulgaris (G. vulgaris) Nees.</p><p><b>METHODS</b>G. vulgaris Nees of the family Apocynaceae is a medium sized tree grown in semishade or no shade and is common in the Ernad and Nilambur taluks of Kerala.Various parts of this plant have been used in the treatment of ulcers, sores, inflammation, dyspepsia, healing of wounds, etc. The present study aimed at the evaluation of anti-inflammatory property of the aqueous and alcoholic extracts of the leaves by both in vitro and in vivo methods. In vitro method was estimated by human red blood cell membrane stabilisation (HRBC) method and in vivo method was estimated on the carrageenan induced paw oedima.</p><p><b>RESULTS</b>Both the methods showed significant anti-inflammatory property of the different extracts tested.</p><p><b>CONCLUSIONS</b>The alcoholic extract at a concentration of 300 mg/mL showed potent activity on comparing with the standard drug diclofenac sodium.</p>